GWS will be without Zac Williams but look set to regain Stephen Coniglio when they attempt to improve their dreadful MCG record this week.
Defender Williams has been ruled out of Sunday's AFL clash with Melbourne due to a hamstring injury suffered in his side's 93-point thrashing of Carlton.
"He's definitely going to miss this week and probably next week but hopefully it's just a minor injury," said coach Leon Cameron on Wednesday
Midfielder Coniglio sat out the Carlton match to help heal a dislocated finger.
"Steve's a big chance," Cameron said.
"He's been playing under a little bit of duress with that finger and having a week off helped but we've just got to make sure if we do send him out this weekend there's no further damage."
Cameron was pleased Shane Mumford was cleared by match review officials earlier in the week, following a big hit in Sunday's clash that landed Blues veteran Marc Murphy in hospital.
"There's no doubt he runs a fine line at times but as a coach, I'm actually rapt that he just wants to put his body on the line for our team," Cameron said.
Cameron will match Mumford in the ruck against Melbourne's Max Gawn for what he expects to be a "huge battle".
"It's a massive challenge for Shane," he said.
"We saw Gawn at his very best last Friday night, it was absolutely outstanding.
"What we've got to discuss is whether we can take in one ruck or two rucks to combat that."
The Giants are hoping to bust their MCG hoodoo on Sunday, having won just two of 16 games played there.
"If I stand up here and say there's no issue at the MCG I would probably be lying," Cameron said.
"We understand we need to step up, (and) the thing I look at the most at the MCG is that we just haven't competed for longer there.
"Defence needs to come to the fore."
Meanwhile the Giants have confirmed contract extensions for forward Daniel Lloyd and ruckman Matthew Flynn.
Thirty-gamer Lloyd has penned a new deal that will see him remain at the club until the end of the 2020 season.
Emerging ruckman Flynn signed a two-year contract extension that locks him up with the Giants until 2021.
Australian Associated Press